Ideally this entry shall become one comprehensive and continuous article.Bulleted lists, for instance, were only used because it is impossible to automatically integrate independent facts into a continuous text.Results: Modification-specific antibodies reveal that peptide substrate amidation is strikingly sensitive to the exposure of cells to moderate hypoxia.
This subsection of the ‘Names and taxonomy’ section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry.
Significance: Physiological effects of hypoxia may be PAM-dependent.
Interactions between biological pathways and molecular oxygen require robust mechanisms for detecting and responding to changes in cellular oxygen availability, in order to support oxygen homeostasis.
Once cleaved, a propeptide generally has no independent biological function.
Peptidyl-glycine alpha-amidating monooxygenase is an enzyme that is required for the biosynthesis of many signaling peptides.